|First appearance||Escape to Beer Mountain: A Rope of Sand|
|Last appearance||Changes: The Big Prom: The Sex Romp: The Season Finale|
|Cause/reason||End of series|
|Portrayed by||Christa Miller|
|Relatives||Drunk Foster Mom|
Cleo is a clone-parody of Cleopatra. Due to her biological counterpart's status as queen, her character sees herself as a social goddess, regularly displaying vanity, egocentrism, manipulation of others and strong narcissism; she is also shown as seductive, promiscuous and libidinous, which helps support her former traits. She is the love interest of both JFK and Abe. Though Cleo is almost always linked with one of the two, she is shown to be very fickle and to switch quite often. While Abe and JFK are practically always in a rivalry over something like the school election, they're usually competing over Cleo's affection. Joan hates Cleo with a passion, both because of her vanity and self-centeredness and Abe's infatuation. Cleo is sometimes shown to recognize that Abe is nicer and a better person than JFK; in fact, in Escape to Beer Mountain: A Rope of Sand, Cleo is at a party with both men and is unsure what course to take. She unknowingly turned to Joan for advice on which to choose. Overcome by guilt, Joan's instruction for Cleo to go with Abe only fueled his ignorance of Joan's love more. Of course, Cleo proved her fickleness by leaving with JFK after Abe revealed the beer he had supplied for the party was non-alcoholic. Because of her popularity, Cleo is driven to perfection; she was student body president multiple times before her term limit ran out, and remains a straight-A student despite an outwardly vacuous facade. It is unknown whether her straight As are a result of her promiscuity or her intelligence. While the first seems possible, she has shown flashes of knowledge and, on more than one occasion, ruins a metaphor by pointing out how it is in fact impossible (such as in Raisin the Stakes: A Rock Opera in Three Acts she points out that love is an abstract concept and therefore can't knock stuff down).
Given that the show is not notable for fidelity to history, Cleo is depicted as a beautiful native Egyptian. Her appearance is clearly based on ancient Egyptian paintings of women, right down to the golden ring in her hair, the show assuming on either side of her head since the paintings were always in profile. In fact her "clone mother" was Macedonian, and judging by surviving portraiture not exactly beautiful either.